Alpha-B-Crystallin Induces an Immune-Regulatory and Antiviral Microglial Response in Preactive Multiple Sclerosis Lesions

Abstract excerpt

Microglial nodules are frequently observed in the normal-appearing white matter of multiple sclerosis (MS) patients. Previously, we have shown that these clusters, which we call "preactive MS lesions," are closely associated with stressed oligodendrocytes and myelin sheaths that contain markedly elevated levels of the small stress protein alpha-B-crystallin (HspB5). Here, we show that microglia in these lesions...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biomarkers in Disease Mechanisms
• Share to Cytokine Signaling Pathways and Interactions
• Share to Leptospirosis research and findings