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Article

Landscape of Somatic Alterations in Thai Pediatric Hepatoblastoma: Implications for Clinical Outcomes and Therapeutic Opportunities.

Medicina (Kaunas, Lithuania) - 15 Apr 2026

Udomwimonsit Rinrabhat, Nokchan Natakorn, Choochuen Pongsakorn, Klaewtanong Yanisa, Sangkhathat Surasak, Sirichamratsakul Kulpreeya

Abstract excerpt

Background and Objectives: Hepatoblastoma (HB) is a rare pediatric liver cancer. Complete resection and chemotherapy are standard treatments, but many patients in developing countries present with unresectable tumors and show poor responses to conventional chemotherapy. Identifying somatic alterations in HB may help develop targeted molecular therapies. Materials and Methods: Exome sequencing was conducted on 34...

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Source

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Identifiers

PMID: 42075635
DOI: 10.3390/medicina62040764
PMCID: PMC13117025

Genes

CTNNB1
FGD4
KMT2D
MUC16
ZNF429

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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