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Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets

7 Jul 2020

Abstract excerpt

Abstract Although hepatoblastoma is the most common pediatric liver cancer, its genetic heterogeneity and therapeutic targets are not well elucidated. Therefore, we conducted a multiomics analysis, including mutatome, DNA methylome, and transcriptome analyses, of 59 hepatoblastoma samples. Based on DNA methylation patterns, hepatoblastoma was classified into three clusters exhibiting remarkable correlation with...

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PMID: 32656360
DOI: 10.1038/s41698-020-0125-y

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