Article
General paucity of genomic alteration and low tumor mutation burden in refractory and metastatic hepatoblastoma: comprehensive genomic profiling study.
Human pathology - 1 Dec 2017
Lee Hwajeong, El Jabbour Tony, Ainechi Sanaz, Gay Laurie M, Elvin Julia A, Vergilio Jo-Anne, Suh James, Ramkissoon Shakti H, Ali Siraj M, Schrock Alexa, Fabrizio David, Frampton Garrett, Nazeer Tipu, Miller Vincent A, Stephens Philip J, Ross Jeffrey S
Abstract excerpt
Hepatoblastoma (HBL) is a hepatic malignancy of infants and young children, which is often cured by combinations of surgery and chemotherapy. Management of refractory and metastatic HBL is challenging. Comprehensive genomic profiling was performed on 31 refractory and metastatic HBL using a hybrid-capture, adaptor ligation-based next-generation sequencing assay. Tumor mutation burden (TMB) was calculated from a...
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