Article
Novel CTNNB1 gene mutations reveal critical pathogenic mechanisms in pediatric hepatoblastoma.
Pediatric surgery international - 26 Jul 2025
Kumar Sourabh, Sharma Jyoti, Pandey Himani, Jain Vishesh, Dhua Anjan Kumar, Yadav Devendra Kumar, Lal Devi, Goel Prabudh
Abstract excerpt
BACKGROUND: Hepatoblastoma (HB) is the most common primary malignant liver tumor in children, with alterations in the Wnt/β-catenin signaling pathway implicated in up to 90% of cases. The CTNNB1, which codes for β-catenin protein, plays a crucial role in this pathway, but its mutation landscape across diverse populations requires further investigation. OBJECTIVES: To analyse and characterize the genetic...
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