Article

CIITA G-286A promoter polymorphism impairs monocytes HLA-DR expression in septic shock and is rescued by interferon-γ

2021-02-23

Abstract excerpt

<h4>ABSTRACT</h4> Monocyte HLA-DR is an increasingly recognized markers of sepsis-induced immunodepression, but its regulatory mechanisms remain poorly understood in sepsis. Several evidence for positive selection on the 5’ promoter region of HLA class II transactivator ( CIITA ) gene, the master regulator of MHC class II, have been gathered in the European population, and its role in sepsis has never been demonst...

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Literature Corpus work: a7816948-9e62-5fa4-9c8f-b110f3b159dc
DOI: 10.1101/2021.02.19.21252097

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