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Article

ROS is the major player in regulating altered autophagy and lifespan in sin-3 mutants of C. elegans.

Autophagy - 1 Jan 2018

Sharma Meenakshi, Pandey Renu, Saluja Daman

Abstract excerpt

SIN3, a transcriptional corepressor has been implicated in varied functions both as transcription activator and repressor. Recent studies associated Sin3 with the macroautophagic/autophagic process as a negative regulator of Atg8 and Atg32. Though the role of SIN3 in autophagy is being explored, little is known about the overall effect of SIN3 deletion on the survival of an organism. In this study using a...

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PMID: 29912629
DOI: 10.1080/15548627.2018.1474312
PMCID: PMC6103711

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PAH

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