Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer

Abstract excerpt

Aims: Sirtuins, a family of NAD + -dependent deacetylases, are recognized as nondispensable regulators of aging processes. Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase that maintains mitochondrial bioenergetics, an essential prerequisite for healthy aging. In this study, using Sirt3 knockout ( Sirt3 −/− ) mice, we sought to establish whether Sirt3 deficiency affected life span, an endpoint that has...

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