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Article

Tra1 controls the transcriptional landscape of the aging cell.

G3 (Bethesda, Md.) - 12 Jan 2023

Bari Khaleda Afrin, Berg Matthew D, Genereaux Julie, Brandl Christopher J, Lajoie Patrick

Abstract excerpt

Gene expression undergoes considerable changes during the aging process. The mechanisms regulating the transcriptional response to cellular aging remain poorly understood. Here, we employ the budding yeast Saccharomyces cerevisiae to better understand how organisms adapt their transcriptome to promote longevity. Chronological lifespan assays in yeast measure the survival of nondividing cells at stationary phase...

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PMID: 36315064
DOI: 10.1093/g3journal/jkac287
PMCID: PMC9836359

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