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SIN-3 transcriptional coregulator maintains mitochondrial homeostasis and polyamine flux

22 Apr 2024

Abstract excerpt

Mitochondrial function relies on the coordinated transcription of mitochondrial and nuclear genomes to assemble respiratory chain complexes. Across species, the SIN3 coregulator influences mitochondrial functions, but how its loss impacts mitochondrial homeostasis and metabolism in the context of a whole organism is unknown. Exploring this link is important because SIN3 haploinsufficiency causes intellectual...

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PMID: 38746662
DOI: 10.1016/j.isci.2024.109789

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