Article

SIN-3 transcriptional coregulator maintains mitochondrial homeostasis and polyamine flux

2023-08-07

Abstract excerpt

Mitochondrial function relies on the coordinated transcription of mitochondrial and nuclear genomes to assemble respiratory chain complexes. Across species, the SIN3 coregulator influences mitochondrial functions, but how its loss impacts mitochondrial homeostasis and metabolism in the context of a whole organism is unknown. Exploring this link is important because SIN3 haploinsufficiency causes intellectual disa...

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Literature Corpus work: 2bfd7b81-788b-53e8-837c-8abbb032dd83
DOI: 10.1101/2023.08.07.552272

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