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Article

Caprine PRNP polymorphisms N146S and Q222K are associated with proteolytic cleavage of PrPC.

Genetics, selection, evolution : GSE - 19 Jun 2021

Madsen-Bouterse Sally A, Stewart Paula, Williamson Helen, Schneider David A, Goldmann Wilfred

Abstract excerpt

Expression of the cellular prion protein (PrPC) is crucial for the development of prion diseases. Amino acid changes in PrPC or a reduced amount of PrPC may modulate disease resistance. The relative abundance of C1, a natural α-cleavage fragment of PrPC, was previously found to be associated with a resistant PRNP genotype in sheep. Goats are another small ruminant where classical scrapie susceptibility is under...

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Identifiers

PMID: 34147084
DOI: 10.1186/s12711-021-00646-x
PMCID: PMC8214774

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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