Article
Simultaneous detection of eight single nucleotide polymorphisms in the ovine prion protein gene.
Molecular and cellular probes - 1 Jan 2000
Benkel Bernhard F, Valle Edith, Bissonnette Nathalie, Hossain Farid A
Abstract excerpt
Amino acid polymorphisms in the prion protein gene (PrP) affect the susceptibility of sheep to scrapie, a transmissible spongiform encephalopathy (TSE). In particular, amino acid substitutions at codons 136, 154 and 171 of the ovine PrP gene are associated with different degrees of susceptibility to the classical form of scrapie, caused by 'typical' scrapie strains. Existing genotyping tests for scrapie...
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