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Article

Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility.

The Journal of cell biology - 10 May 2004

Subauste M Cecilia, Pertz Olivier, Adamson Eileen D, Turner Christopher E, Junger Sachiko, Hahn Klaus M

Abstract excerpt

Cells lacking vinculin are highly metastatic and motile. The reasons for this finding have remained unclear. Both enhanced survival and motility are critical to metastasis. Here, we show that vinculin null (vin-/-) cells and cells expressing a vinculin Y822F mutant have increased survival due to up-regulated activity of extracellular signal-regulated kinase (ERK). This increase is shown to result from vinculin's...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15138291
DOI: 10.1083/jcb.200308011
PMCID: PMC2172187

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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