Article
KIR B haplotype donors confer a reduced risk for relapse after haploidentical transplantation in children with ALL.
Blood - 23 Oct 2014
Oevermann Lena, Michaelis Sebastian U, Mezger Markus, Lang Peter, Toporski Jacek, Bertaina Alice, Zecca Marco, Moretta Lorenzo, Locatelli Franco, Handgretinger Rupert
Abstract excerpt
We analyzed the influence of donor killer-cell immunoglobulin-like receptor (KIR) gene haplotypes on the risk for relapse and the probability of event-free survival (EFS) in children with acute lymphoblastic leukemia who received human leukocyte antigen-haploidentical transplantation of ex vivo T-cell-depleted peripheral blood stem cells. The KIR gene haplotype was evaluated in 85 donors, and the KIR B content...
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