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KIR B donors improve the outcome for AML patients given reduced intensity conditioning and unrelated donor transplantation

24 Feb 2020

Abstract excerpt

Natural killer (NK) cell recognition and killing of target cells are enhanced when inhibitory killer immunoglobulin-like receptors (KIR) are unable to engage their cognate HLA class I ligands. The genes of the KIR locus are organized into either KIR B haplotypes, containing 1 or more activating KIR genes or KIR A haplotypes, which lack those genes. Analysis of unrelated donor (URD) hematopoietic cell transplants...

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PMID: 32092137
DOI: 10.1182/bloodadvances.2019001053

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