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Article

Donor KIR Genotype Impacts on Clinical Outcome after T Cell-Depleted HLA Matched Related Allogeneic Transplantation for High-Risk Pediatric Leukemia Patients.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Dec 2018

Escudero Adela, Martínez-Romera Isabel, Fernández Lucía, Valentín Jaime, González-Vicent Marta, Vicario José Luis, Madero-Jarabo Rosario, Diaz Miguel Ángel, Pérez-Martínez Antonio

Abstract excerpt

Preliminary data suggest that ex vivo T cell-depleted matched related donor (MRD) hematopoietic stem cell transplantation (HSCT) is feasible and confers a clinically beneficial reduction in graft-versus-host disease. Classically, T cell-depleted grafts were associated with reduction of the graft-versus-leukemia (GVL) effect because of delayed T cell immune reconstitution. However, natural killer (NK) cell...

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Share to Child, Preschool
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Infant, Newborn

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Share to Receptors, KIR

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Source

Identifiers

PMID: 30145228
DOI: 10.1016/j.bbmt.2018.08.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Donor KIR Genotype Impacts on Clinical Outcome after T Cell-Depleted HLA Matched Related Allogeneic Transplantation for High-Risk Pediatric Leukemia Patients.PMID 30145228Read ↗

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