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Article

Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia.

Blood - 15 Jan 2009

Cooley Sarah, Trachtenberg Elizabeth, Bergemann Tracy L, Saeteurn Koy, Klein John, Le Chap T, Marsh Steven G E, Guethlein Lisbeth A, Parham Peter, Miller Jeffrey S, Weisdorf Daniel J

Abstract excerpt

Survival for patients with acute myeloid leukemia (AML) is limited by treatment-related mortality (TRM) and relapse after unrelated donor (URD) hematopoietic cell transplantation (HCT). Natural killer (NK)-cell alloreactivity, determined by donor killer-cell immunoglobulin-like receptors (KIRs) and recipient HLA, correlates with successful HCT for AML. Hypothesizing that donor KIR genotype (A/A: 2 A KIR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to HLA Antigens

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Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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Source

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Identifiers

PMID: 18945962
DOI: 10.1182/blood-2008-07-171926
PMCID: PMC2628378

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