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Article

Genetic Regulation ofZfp30, CXCL1, and Neutrophilic Inflammation in Murine Lung

11 Aug 2014

Abstract excerpt

Allergic asthma is a complex disease characterized in part by granulocytic inflammation of the airways. In addition to eosinophils, neutrophils (PMN) are also present, particularly in cases of severe asthma. We sought to identify the genetic determinants of neutrophilic inflammation in a mouse model of house dust mite (HDM)-induced asthma. We applied an HDM model of allergic asthma to the eight founder strains of...

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PMID: 25114278
DOI: 10.1534/genetics.114.168138

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