Article
Genetic variation associates with susceptibility for cigarette smoke-induced neutrophilia in mice.
American journal of physiology. Lung cellular and molecular physiology - 1 Apr 2015
Pouwels Simon D, Heijink Irene H, Brouwer Uilke, Gras Renee, den Boef Lisette E, Boezen H Marike, Korstanje Ron, van Oosterhout Antoon J M, Nawijn Martijn C
Abstract excerpt
Neutrophilic airway inflammation is one of the major hallmarks of chronic obstructive pulmonary disease and is also seen in steroid resistant asthma. Neutrophilic airway inflammation can be induced by different stimuli including cigarette smoke (CS). Short-term exposure to CS induces neutrophilic airway inflammation in both mice and humans. Since not all individuals develop extensive neutrophilic airway...
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