Article
Cox4i2, Ifit2, and Prdm11 Mutant Mice: Effective Selection of Genes Predisposing to an Altered Airway Inflammatory Response from a Large Compendium of Mutant Mouse Lines.
PloS one - 1 Jan 2015
Horsch Marion, Aguilar-Pimentel Juan Antonio, Bönisch Clemens, Côme Christophe, Kolster-Fog Cathrine, Jensen Klaus T, Lund Anders H, Lee Icksoo, Grossman Lawrence I, Sinkler Christopher, Hüttemann Maik, Bohn Erwin, Fuchs Helmut, Ollert Markus, Gailus-Durner Valérie, de Angelis Martin Hrabĕ, Beckers Johannes
Abstract excerpt
We established a selection strategy to identify new models for an altered airway inflammatory response from a large compendium of mutant mouse lines that were systemically phenotyped in the German Mouse Clinic (GMC). As selection criteria we included published gene functional data, as well as immunological and transcriptome data from GMC phenotyping screens under standard conditions. Applying these criteria we...
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