Article
Identification of microRNAs associated with allergic airway disease using a genetically diverse mouse population.
BMC genomics - 25 Aug 2015
Rutledge Holly, Baran-Gale Jeanette, de Villena Fernando Pardo-Manuel, Chesler Elissa J, Churchill Gary A, Sethupathy Praveen, Kelada Samir N P
Abstract excerpt
BACKGROUND: Allergic airway diseases (AADs) such as asthma are characterized in part by granulocytic airway inflammation. The gene regulatory networks that govern granulocyte recruitment are poorly understood, but evidence is accruing that microRNAs (miRNAs) play an important role. To identify miRNAs that may underlie AADs, we used two complementary approaches that leveraged the genotypic and phenotypic diversity...
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