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Article

Functional and structural characterization of the kinase insert and the carboxy terminal domain in VEGF receptor 2 activation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2014

Manni Sandro, Kisko Kaisa, Schleier Thomas, Missimer Jack, Ballmer-Hofer Kurt

Abstract excerpt

Vascular endothelial growth factors (VEGFs) regulate blood and lymphatic vessel development and homeostasis. VEGF receptor 2 (VEGFR-2) is the major receptor involved in vasculogenesis and angiogenesis and regulates endothelial cell survival, migration, and mitogenesis. Ligand-mediated receptor dimerization instigates transmembrane signaling, thereby promoting activation of the intracellular kinase domain. The...

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PMID: 25114179
DOI: 10.1096/fj.14-256206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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