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Article

Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation.

Proceedings of the National Academy of Sciences of the United States of America - 6 Aug 2013

Leppänen Veli-Matti, Tvorogov Denis, Kisko Kaisa, Prota Andrea E, Jeltsch Michael, Anisimov Andrey, Markovic-Mueller Sandra, Stuttfeld Edward, Goldie Kenneth N, Ballmer-Hofer Kurt, Alitalo Kari

Abstract excerpt

Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are key drivers of blood and lymph vessel formation in development, but also in several pathological processes. VEGF-C signaling through VEGFR-3 promotes lymphangiogenesis, which is a clinically relevant target for treating lymphatic insufficiency and for blocking tumor angiogenesis and metastasis. The extracellular domain of VEGFRs consists...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 23878260
DOI: 10.1073/pnas.1301415110
PMCID: PMC3740881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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