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Article

Preparation of human vascular endothelial growth factor-D for structural and preclinical therapeutic studies.

Protein expression and purification - 1 Mar 2012

Davydova Natalia, Streltsov Victor A, Roufail Sally, Lovrecz George O, Stacker Steven A, Adams Timothy E, Achen Marc G

Abstract excerpt

Vascular endothelial growth factor-D (VEGF-D), a secreted angiogenic and lymphangiogenic glycoprotein, enhances tumor growth and metastasis in animal models, and its expression correlates with metastasis and poor patient outcome in some cancers - it is therefore considered a target for novel anti-cancer therapeutics. The definition of the structure of the complex of VEGF-D bound to its receptors would be...

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Source

Identifiers

PMID: 22261343
DOI: 10.1016/j.pep.2012.01.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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