Article
Mutation in the Kinase Domain Alters the VEGFR2 Membrane Dynamics.
Cells - 13 Aug 2024
Corsini Michela, Ravelli Cosetta, Grillo Elisabetta, Domenichini Mattia, Mitola Stefania
Abstract excerpt
BACKGROUND: Recently, the substitution R1051Q in VEGFR2 has been described as a cancer-associated "gain of function" mutation. VEGFR2R1051Q phosphorylation is ligand-independent and enhances the activation of intracellular pathways and cell growth both in vitro and in vivo. In cancer, this mutation is found in heterozygosity, suggesting that an interaction between VEGFR2R1051Q and VEGFR2WT may occur and could...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.