Article
Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2007
McColl Bradley K, Paavonen Karri, Karnezis Tara, Harris Nicole C, Davydova Natalia, Rothacker Julie, Nice Edouard C, Harder Kenneth W, Roufail Sally, Hibbs Margaret L, Rogers Peter A W, Alitalo Kari, Stacker Steven A, Achen Marc G
Abstract excerpt
Vascular endothelial growth factor (VEGF)-D is a secreted glycoprotein that induces angiogenesis and lymphangiogenesis. It consists of a central domain, containing binding sites for VEGF receptor-2 (VEGFR-2) and VEGFR-3, and N- and C-terminal propeptides. It is secreted from the cell as homodimers of the full-length form that can be proteolytically processed to remove the propeptides. It was recently shown, using...
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