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Article

Identification of specific molecular structures of human immunodeficiency virus type 1 Tat relevant for its biological effects on vascular endothelial cells.

Journal of virology - 1 Jan 2000

Mitola S, Soldi R, Zanon I, Barra L, Gutierrez M I, Berkhout B, Giacca M, Bussolino F

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) Tat transactivates viral genes and is released by infected cells, acting as a soluble mediator. In endothelial cells (EC), it activates a proangiogenic program by activating vascular endothelial growth factor receptor type 2 (VEGFR-2) and integrins. A structure-activity relationship study was performed by functional analysis of Tat substitution and deletion variants to...

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Source

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Identifiers

PMID: 10590123
DOI: 10.1128/jvi.74.1.344-353.2000
PMCID: PMC111545

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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