Article
Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition.
Structure (London, England : 1993) - 1 May 2005
Barton William A, Tzvetkova Dorothea, Nikolov Dimitar B
Abstract excerpt
The angiopoietins comprise a small class of secreted glycoproteins that play crucial roles in the maturation and maintenance of the mammalian vascular and lymphatic systems. They exert their effects through a member of the tyrosine kinase receptor family, Tie2. Angiopoietin/Tie2 signaling is unique among tyrosine kinase receptor-ligand systems in that distinct angiopoietin ligands, although highly homologous, can...
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