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Article

Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 1997

Muller Y A, Li B, Christinger H W, Wells J A, Cunningham B C, de Vos A M

Abstract excerpt

Vascular endothelial growth factor (VEGF) is a homodimeric member of the cystine knot family of growth factors, with limited sequence homology to platelet-derived growth factor (PDGF) and transforming growth factor beta2 (TGF-beta). We have determined its crystal structure at a resolution of 2.5 A, and identified its kinase domain receptor (KDR) binding site using mutational analysis. Overall, the VEGF monomer...

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Source

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Identifiers

PMID: 9207067
DOI: 10.1073/pnas.94.14.7192
PMCID: PMC23789

Genes

KDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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