Article
Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 1997
Muller Y A, Li B, Christinger H W, Wells J A, Cunningham B C, de Vos A M
Abstract excerpt
Vascular endothelial growth factor (VEGF) is a homodimeric member of the cystine knot family of growth factors, with limited sequence homology to platelet-derived growth factor (PDGF) and transforming growth factor beta2 (TGF-beta). We have determined its crystal structure at a resolution of 2.5...
Topics
- Binding Sites
- Crystallization
- Endothelial Growth Factors
- Escherichia coli
- Lymphokines
- Molecular Sequence Data
- Mutation
- Peptide Mapping
- Receptor Protein-Tyrosine Kinases
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors