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Article

Structural determinants of vascular endothelial growth factor-D receptor binding and specificity.

Blood - 3 Feb 2011

Leppänen Veli-Matti, Jeltsch Michael, Anisimov Andrey, Tvorogov Denis, Aho Kukka, Kalkkinen Nisse, Toivanen Pyry, Ylä-Herttuala Seppo, Ballmer-Hofer Kurt, Alitalo Kari

Abstract excerpt

Vascular endothelial growth factors (VEGFs) and their tyrosine kinase receptors (VEGFR-1-3) are central mediators of angiogenesis and lymphangiogenesis. VEGFR-3 ligands VEGF-C and VEGF-D are produced as precursor proteins with long N- and C-terminal propeptides and show enhanced VEGFR-2 and VEGFR-3 binding on proteolytic removal of the propeptides. Two different proteolytic cleavage sites have been reported in...

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PMID: 21148085
DOI: 10.1182/blood-2010-08-301549

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