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Article

Dimerization of Tie2 mediated by its membrane-proximal FNIII domains.

Proceedings of the National Academy of Sciences of the United States of America - 25 Apr 2017

Moore Jason O, Lemmon Mark A, Ferguson Kathryn M

Abstract excerpt

Tie1 and Tie2, members of the tyrosine kinase family with immunoglobulin and EGF homology domains, are receptor tyrosine kinases found primarily in endothelial cells with key roles in development and maintenance of the vasculature and in angiogenesis. They are attractive targets for therapeutic intervention in tumor angiogenesis, inflammation, and sepsis. Tie2 is regulated directly by the multimeric angiopoietin...

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Identifiers

PMID: 28396397
DOI: 10.1073/pnas.1617800114
PMCID: PMC5410832

Genes

EGF

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