Cell death induced by 2-phenylethynesulfonamide uncovers a pro-survival function of BAX.

Abstract excerpt

PES (2-phenylethynesulfonamide) was initially identified as an inhibitor of p53 translocation to mitochondria and named Pifithrin-µ. Further studies showed that PES selectively killed tumour cells and was thus a promising anticancer agent. PES-induced cell death was characterised by a non-apoptotic, autophagosome-rich phenotype. We observed this phenotype via electron microscopy in wild type (wt) and double...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to bcl-2-Associated X Protein
• Share to Caspases
• Share to Cell Death