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Article

Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak‐independent death of cancer cells

11 Apr 2012

Abstract excerpt

Overcoming the resistance of tumours to chemotherapy, often due to downregulation of Bax and Bak, represents a significant clinical challenge. It is therefore important to identify novel apoptosis inducers that bypass Bax and Bak. Potassium channels are emerging as oncological targets and a crucial role of mitochondrial Kv1.3 in apoptosis has been demonstrated. Here we report for the first time that Psora-4,...

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PMID: 22496117
DOI: 10.1002/emmm.201200235

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