The Mitochondrial F0F1-ATPase proton pump is required for function of the proapoptotic protein Bax in yeast and mammalian cells.

doi:10.1016/s1097-2765(00)80033-7

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Article

The Mitochondrial F0F1-ATPase proton pump is required for function of the proapoptotic protein Bax in yeast and mammalian cells.

Molecular cell - 1 Feb 1998

Matsuyama S, Xu Q, Velours J, Reed J C

Abstract excerpt

The proapoptotic mammalian protein Bax associates with mitochondrial membranes and confers a lethal phenotype when expressed in yeast. By generating Bax-resistant mutant yeast and using classical complementation cloning methods, subunits of the mitochondrial F0F1-ATPase proton pump were determine...

Topics

Animals
Apoptosis
Cell Respiration
Cells, Cultured
Cloning, Molecular
Eukaryotic Cells
Genes, Fungal
Genetic Complementation Test
Kidney
Mammals
Mutation
Oligomycins
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Proton-Translocating ATPases
Rats
Saccharomyces cerevisiae
Tumor Suppressor Protein p53

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Identifiers

PMID: 9660917
DOI: 10.1016/s1097-2765(00)80033-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9660917-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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