Article
Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 2008
Szabó Ildikò, Bock Jürgen, Grassmé Heike, Soddemann Matthias, Wilker Barbara, Lang Florian, Zoratti Mario, Gulbins Erich
Abstract excerpt
The potassium channel Kv1.3 has recently been located to the inner mitochondrial membrane of lymphocytes. Here, we show that mouse and human cells either genetically deficient in Kv1.3 or transfected with siRNA to suppress Kv1.3-expression resisted apoptosis induced by several stimuli, including Bax over-expression [corrected]. Retransfection of either Kv1.3 or a mitochondrial-targeted Kv1.3 restored cell death ....
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