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Article

Key role of mitochondria in cerulenin-mediated apoptosis.

Cell death and differentiation - 1 Sept 2002

Heiligtag S J, Bredehorst R, David K A

Abstract excerpt

Cerulenin, a fungal metabolite, is known to be a specific inhibitor of fatty acid synthase. Here we report that cerulenin is an effective inducer of apoptosis in different wild-type p53 and mutant p53 tumor cell lines, whereas normal human keratinocytes and fibroblasts are resistant to the apopto...

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Identifiers

PMID: 12181752
DOI: 10.1038/sj.cdd.4401055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12181752-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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