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Article

MicroRNA-mediated repression of nonsense mRNAs.

eLife - 8 Aug 2014

Zhao Ya, Lin Jimin, Xu Beiying, Hu Sida, Zhang Xue, Wu Ligang

Abstract excerpt

Numerous studies have established important roles for microRNAs (miRNAs) in regulating gene expression. Here, we report that miRNAs also serve as a surveillance system to repress the expression of nonsense mRNAs that may produce harmful truncated proteins. Upon recognition of the premature termination codon by the translating ribosome, the downstream portion of the coding region of an mRNA is redefined as part of...

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PMID: 25107276
DOI: 10.7554/eLife.03032
PMCID: PMC4359369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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