Article
The meaning of nonsense.
Trends in cell biology - 1 Jul 2008
Stalder Lukas, Mühlemann Oliver
Abstract excerpt
To ensure the accuracy of gene expression, eukaryotes have evolved several surveillance mechanisms. One of the best-studied quality control mechanisms is nonsense-mediated mRNA decay (NMD), which recognizes and degrades transcripts harboring a premature translation-termination codon (PTC), thereby preventing the production of faulty proteins. NMD regulates approximately 10% of human mRNAs, and its physiological...
Topics
- Animals
- Caenorhabditis elegans
- Drosophila melanogaster
- Evolution, Molecular
- Gene Expression Regulation
- Genetic Diseases, Inborn
- Humans
- Models, Biological
- Mutation
- Protein Biosynthesis
- Protein Structure, Tertiary