Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RNA splicing promotes translation and RNA surveillance.

Nature structural & molecular biology - 1 Sept 2005

Gudikote Jayanthi P, Imam J Saadi, Garcia Ramon F, Wilkinson Miles F

Abstract excerpt

Aberrant mRNAs harboring premature termination codons (PTCs or nonsense codons) are degraded by the nonsense-mediated mRNA decay (NMD) pathway. mRNAs transcribed from genes that naturally acquire PTCs during lymphocyte development are strongly downregulated by PTCs. Here we show that a signal essential for this robust mRNA downregulatory response is efficient RNA splicing. Strong mRNA downregulation can be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA Splicing
Share to Down-Regulation
Share to HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Introns

Share to Protein Biosynthesis

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to RNA Splice Sites

Source

Identifiers

PMID: 16116435
DOI: 10.1038/nsmb980

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RNA splicing promotes translation and RNA surveillance.PMID 16116435Read ↗

mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons.Semantic proximity Read ↗

The rules and impact of nonsense-mediated mRNA decay in human cancers.Semantic proximity Read ↗

A Quality Control Pathway That Down-regulates Aberrant T-cell Receptor (TCR) Transcripts by a Mechanism Requiring UPF2 and TranslationSemantic proximity Read ↗

Nonsense-mediated mRNA decay modulates clinical outcome of genetic disease.Semantic proximity Read ↗

NMD: RNA biology meets human genetic medicine.Semantic proximity Read ↗

Mechanism, factors, and physiological role of nonsense-mediated mRNA decay.Semantic proximity Read ↗

Transcription-coupled RNA surveillance in human genetic diseases caused by splice site mutations.Semantic proximity Read ↗

Novel autoregulatory cases of alternative splicing coupled with nonsense-mediated mRNA decaySemantic proximity Read ↗

Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.Semantic proximity Read ↗

The meaning of nonsense.Semantic proximity Read ↗

Direct and indirect effects of spliceosome disruption compromise gene regulation by Nonsense-Mediated mRNA DecaySemantic proximity Read ↗

Transcriptome analysis of alternative splicing-coupled nonsense-mediated mRNA decay in human cells reveals broad regulatory potentialSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.