Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The rules and impact of nonsense-mediated mRNA decay in human cancers.

Nature genetics - 1 Oct 2016

Lindeboom Rik G H, Supek Fran, Lehner Ben

Abstract excerpt

Premature termination codons (PTCs) cause a large proportion of inherited human genetic diseases. PTC-containing transcripts can be degraded by an mRNA surveillance pathway termed nonsense-mediated mRNA decay (NMD). However, the efficiency of NMD varies; it is inefficient when a PTC is located downstream of the last exon junction complex (EJC). We used matched exome and transcriptome data from 9,769 human tumors...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Codon, Nonsense
Share to Codon, Terminator
Share to Drosophila

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Neoplasms

Share to Nonsense Mediated mRNA Decay

Share to Protein Biosynthesis

Source

Open in PubMed Open full text

Identifiers

PMID: 27618451
DOI: 10.1038/ng.3664
PMCID: PMC5045715

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The rules and impact of nonsense-mediated mRNA decay in human cancers.PMID 27618451Read ↗

Genomic stop codon scanning reveals quantitative principles of nonsense-mediated mRNA decaySemantic proximity Read ↗

Quantitative prediction of nonsense-mediated mRNA decay across human genes by genomic language model and large-scale mutational scanningSemantic proximity Read ↗

Regional nonsense constraint offers clinical and biological insights into rare genetic disordersSemantic proximity Read ↗

NMD: RNA biology meets human genetic medicine.Semantic proximity Read ↗

Nonsense-mediated RNA decay and its bipolar function in cancer.Semantic proximity Read ↗

mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons.Semantic proximity Read ↗

Nonsense-mediated mRNA decay modulates clinical outcome of genetic disease.Semantic proximity Read ↗

Regional nonsense constraint offers biological and clinical insights into genetic disease.Semantic proximity Read ↗

Variable efficiency of nonsense-mediated mRNA decay across human tissues, tumors and individualsSemantic proximity Read ↗

Nonsense-mediated mRNA decay: inter-individual variability and human disease.Semantic proximity Read ↗

The meaning of nonsense.Semantic proximity Read ↗

Systematic analysis of nonsense variants uncovers peptide release rate as a novel modifier of nonsense-mediated mRNA decaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.