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Article

The rules and impact of nonsense-mediated mRNA decay in human cancers.

Nature genetics - 1 Oct 2016

Lindeboom Rik G H, Supek Fran, Lehner Ben

Abstract excerpt

Premature termination codons (PTCs) cause a large proportion of inherited human genetic diseases. PTC-containing transcripts can be degraded by an mRNA surveillance pathway termed nonsense-mediated mRNA decay (NMD). However, the efficiency of NMD varies; it is inefficient when a PTC is located downstream of the last exon junction complex (EJC). We used matched exome and transcriptome data from 9,769 human tumors...

Topics

Animals
Codon, Nonsense
Codon, Terminator
Drosophila
Exons
Genes, Tumor Suppressor
Humans
Models, Genetic
Mutation
Neoplasms
Nonsense Mediated mRNA Decay
Protein Biosynthesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27618451
DOI: 10.1038/ng.3664
PMCID: PMC5045715

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