Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of Nonsense Mutations by New Emerging Technologies.

International journal of molecular sciences - 20 Jun 2020

Morais Pedro, Adachi Hironori, Yu Yi-Tao

Abstract excerpt

Nonsense mutations often result from single nucleotide substitutions that change a sense codon (coding for an amino acid) to a nonsense or premature termination codon (PTC) within the coding region of a gene. The impact of nonsense mutations is two-fold: (1) the PTC-containing mRNA is degraded by a surveillance pathway called nonsense-mediated mRNA decay (NMD) and (2) protein translation stops prematurely at the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clinical Trials as Topic
Share to Codon, Nonsense
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nonsense Mediated mRNA Decay

Share to Polymorphism, Single Nucleotide

Share to Precision Medicine

Share to RNA, Messenger

Share to Small Molecule Libraries

Source

Open in PubMed Open full text

Identifiers

PMID: 32575694
DOI: 10.3390/ijms21124394
PMCID: PMC7352488

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of Nonsense Mutations by New Emerging Technologies.PMID 32575694Read ↗

Therapeutic promise of engineered nonsense suppressor tRNAs.Semantic proximity Read ↗

Targeting Nonsense Mutations in Diseases with Translational Read-Through-Inducing Drugs (TRIDs).Semantic proximity Read ↗

Nonsense Suppression as an Approach to Treat Lysosomal Storage DiseasesSemantic proximity Read ↗

Introducing sense into nonsense in treatments of human genetic diseases.Semantic proximity Read ↗

mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons.Semantic proximity Read ↗

The meaning of nonsense.Semantic proximity Read ↗

Nonsense-mediated RNA decay and its bipolar function in cancer.Semantic proximity Read ↗

Nonsense-mediated mRNA decay modulates clinical outcome of genetic disease.Semantic proximity Read ↗

Nonsense Mutations in Eukaryotes.Semantic proximity Read ↗

PTC124 targets genetic disorders caused by nonsense mutations.Semantic proximity Read ↗

Readthrough Activators and Nonsense-Mediated mRNA Decay Inhibitor Molecules: Real Potential in Many Genetic Diseases Harboring Premature Termination CodonsSemantic proximity Read ↗

Fluorescence Amplification Method for Forward Genetic Discovery of Factors in Human mRNA Degradation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.