Article
Myofiber-specific inhibition of TGFβ signaling protects skeletal muscle from injury and dystrophic disease in mice.
Human molecular genetics - 20 Dec 2014
Accornero Federica, Kanisicak Onur, Tjondrokoesoemo Andoria, Attia Aria C, McNally Elizabeth M, Molkentin Jeffery D
Abstract excerpt
Muscular dystrophy (MD) is a disease characterized by skeletal muscle necrosis and the progressive accumulation of fibrotic tissue. While transforming growth factor (TGF)-β has emerged as central effector of MD and fibrotic disease, the cell types in diseased muscle that underlie TGFβ-dependent pathology have not been segregated. Here, we generated transgenic mice with myofiber-specific inhibition of TGFβ...
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