Article
Tuning Macrophage Phenotype to Mitigate Skeletal Muscle Fibrosis.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2020
Stepien David M, Hwang Charles, Marini Simone, Pagani Chase A, Sorkin Michael, Visser Noelle D, Huber Amanda K, Edwards Nicole J, Loder Shawn J, Vasquez Kaetlin, Aguilar Carlos A, Kumar Ravi, Mascharak Shamik, Longaker Michael T, Li Jun, Levi Benjamin
Abstract excerpt
Myeloid cells are critical to the development of fibrosis following muscle injury; however, the mechanism of their role in fibrosis formation remains unclear. In this study, we demonstrate that myeloid cell-derived TGF-β1 signaling is increased in a profibrotic ischemia reperfusion and cardiotoxin muscle injury model. We found that myeloid-specific deletion of Tgfb1 abrogates the fibrotic response in this injury...
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