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Depletion of skeletal muscle satellite cells attenuates pathology in muscular dystrophy

26 May 2022

Abstract excerpt

Skeletal muscle can repair and regenerate due to resident stem cells known as satellite cells. The muscular dystrophies are progressive muscle wasting diseases underscored by chronic muscle damage that is continually repaired by satellite cell-driven regeneration. Here we generate a genetic strategy to mediate satellite cell ablation in dystrophic mouse models to investigate how satellite cells impact disease...

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PMID: 35618700
DOI: 10.1038/s41467-022-30619-7

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