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Article

PDGFRα signalling promotes fibrogenic responses in collagen-producing cells in Duchenne muscular dystrophy.

The Journal of pathology - 1 Dec 2016

Ieronimakis Nicholas, Hays Aislinn, Prasad Amalthiya, Janebodin Kajohnkiart, Duffield Jeremy S, Reyes Morayma

Abstract excerpt

Fibrosis is a characteristic of Duchenne muscular dystrophy (DMD), yet the cellular and molecular mechanisms responsible for DMD fibrosis are poorly understood. Utilizing the Collagen1a1-GFP transgene to identify cells producing Collagen-I matrix in wild-type mice exposed to toxic injury or those mutated at the dystrophin gene locus (mdx) as a model of DMD, we studied mechanisms of skeletal muscle injury/repair...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscular Dystrophy, Duchenne

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Share to Receptor, Platelet-Derived Growth Factor alpha

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Source

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Identifiers

PMID: 27569721
DOI: 10.1002/path.4801
PMCID: PMC5113675

Genes

DMD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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