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Article

Conditional expression of TGF-β1 in skeletal muscles causes endomysial fibrosis and myofibers atrophy.

PloS one - 1 Jan 2013

Narola Jigna, Pandey Sachchida Nand, Glick Adam, Chen Yi-Wen

Abstract excerpt

To study the effects of transforming growth factor beta 1 (TGF-β1) on fibrosis and failure of regeneration of skeletal muscles, we generated a tet-repressible muscle-specific TGF-β1 transgenic mouse in which expression of TGF-β1 is controlled by oral doxycycline. The mice developed muscle weakness and atrophy after TGF-β1 over-expression. We defined the group of mice that showed phenotype within 2 weeks as early...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24244485
DOI: 10.1371/journal.pone.0079356
PMCID: PMC3828351

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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