Article

Satellite cell depletion in early adulthood attenuates muscular dystrophy pathogenesis

2019-11-28

Abstract excerpt

Satellite cells are skeletal muscle resident stem cells that regenerate adult myofibers following an acute injury to muscle. Despite the assumption that the loss of satellite cells would be detrimental in a chronic regeneration-inducing muscle disease such as muscular dystrophy, this assumption has never been tested using mouse genetics. Here we generated a novel model of satellite cell ablation and crossed it wit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 23e14b39-7d12-5933-a1d5-b03962965e99
DOI: 10.1101/857433

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Satellite cell depletion in early adulthood attenuates muscular dystrophy pathogenesisDOI 10.1101/857433Read

Depletion of skeletal muscle satellite cells attenuates pathology in muscular dystrophySemantic proximity Read

Satellite cells from dystrophic muscle retain regenerative capacitySemantic proximity Read

SMN depletion impairs skeletal muscle formation and maturation in a mouse model of SMASemantic proximity Read

Stem cells for skeletal muscle repairSemantic proximity Read

Notch signaling deficiency underlies age-dependent depletion of satellite cells in muscular dystrophySemantic proximity Read

Muscle stem cells contribute to myofibres in sedentary adult mice.Semantic proximity Read

Skeletal muscle in health and diseaseSemantic proximity Read

Cellular pathogenesis of Duchenne muscular dystrophy: progressive myofibre degeneration, chronic inflammation, reactive myofibrosis and satellite cell dysfunctionSemantic proximity Read

The altered fate of aging satellite cells is determined by signaling and epigenetic changesSemantic proximity Read

Muscle stem cells in Duchenne muscular dystrophy exhibit molecular impairments and altered cell fate trajectories impacting regenerative capacitySemantic proximity Read

Isolation, characterization, and molecular regulation of muscle stem cellsSemantic proximity Read

Brief Report: Blockade of Notch Signaling in Muscle Stem Cells Causes Muscular Dystrophic Phenotype and Impaired Muscle RegenerationSemantic proximity Read