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Article

Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice

19 Nov 2019

Abstract excerpt

Caloric restriction has been associated with increased life span and reduced aging-related disorders and reduces fibrosis in several diseases. Fibrosis is characterized by deposition of excess fibrous material in tissues and organs and is caused by aging, chronic stress, injury, or disease. Myofibroblasts are fibroblast-like cells that secrete high levels of extracellular matrix proteins, resulting in fibrosis....

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PMID: 31744885
DOI: 10.1074/jbc.ra118.007212

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