Article
A new calmodulin-binding motif for inositol 1,4,5-trisphosphate 3-kinase regulation.
The Biochemical journal - 1 Nov 2014
Franco-Echevarría Elsa, Baños-Sanz Jose I, Monterroso Begoña, Round Adam, Sanz-Aparicio Julia, González Beatriz
Abstract excerpt
IP3-3K [Ins(1,4,5)P3 3-kinase] is a key enzyme that catalyses the synthesis of Ins(1,3,4,5)P4, using Ins(1,4,5)P3 and ATP as substrates. Both inositides, substrate and product, present crucial roles in the cell. Ins(1,4,5)P3 is a key point in Ca2+ metabolism that promotes Ca2+ release from intracellular stores and together with Ins(1,3,4,5)P4 regulates Ca2+ homoeostasis. In addition, Ins(1,3,4,5)P4 is involved in...
Topics
- Amino Acid Motifs
- Binding Sites
- Calmodulin
- Crystallography, X-Ray
- Enzyme Activation
- Humans
- Isoenzymes
- Mutation
- Phosphotransferases (Alcohol Group Acceptor)
- Protein Binding
- Protein Conformation